As per Ancient text, one of the Triphala formulation called as Chinnodbhavadi kwath (decoction) is used for chronic hyperacidity and gastro-intestinal problems. Triphala is categorized as Ayurvedic rejuvenator and antioxidant rich herbal formulation. The aim of present study was to ascertain whether the intestinal protective effect of Triphala formulations is retained when Triphala formulation used as an ingredients of Chinnodbhavadi kwath to substantiate its traditional claim. Intestinal damage was induced by administering methotrexate (MTX) in a dose of 12 mg/kg, orally for 4 days to albino rats. The intestinal damage response was assessed by measuring the intestinal permeability to phenol red and tissue biochemical parameters. Chinnodbhavadi kwath at the dose of 8.7 ml/kg significantly restored the depleted level of disaccharidases and ATPases content in basolateral membrane of intestine (BBMV) and decreased the myeloperoxidase and xanthine oxidase level in intestinal mucosa of MTX treated rats. However permeation clearance of phenol red through damaged intestinal mucosa not affected at significant level. Based on the data generated it is suggested that Chinnodbhavadi kwath provides moderate protection against methotrexate induced damage in rat intestine.
Loading....